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Dexfenfluramine and pergolide cause heart valve disease via valve metabolic reprogramming and ongoing matrix remodeling

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NF-B is a key transcriptional regulator of inflammatory mediators and leads to, for example, increased expression of TNF-, IL-6, IL-8, E-selectin, VCAM-1, and ICAM-1 [166,167,168]

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Homocysteine, an atherogenic stimulus, reduces protein C activation by arterial and venous endothelial cells

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