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Morphine reduces PVN Glu neuronal activity via MOR to induce constipation MOR activation has been shown to modulate neuronal function through well-established G protein signaling mechanisms, such as postsynaptic activation of G protein-coupled inwardly rectifying potassium channels, which causes hyperpolarization and inhibition of neurons 29,30,31

This activation triggers several glucose-lowering mechanisms: Enhanced insulin secretion : These agents stimulate insulin release from pancreatic beta cells in a glucose-dependent manner, meaning insulin secretion increases only when blood glucose levels are elevated, reducing hypoglycaemia risk

Keeping your body hydrated is critical on GLP-1 medications to keep you feeling your best and avoid side effects