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Accumulation of misfolded proteins leads to the dissociation of BiP from the three UPR sensors ( Figure 2F ) (27, 28)

(6) Although historically used as an organophosphate antiglaucoma agent, echothiophate is now largely obsolete because safer and more effective therapies, including prostaglandin analogs and topical adrenergic antagonists, have replaced its routine clinical use

Muscles are the main reservoir of carnitine, storing 95% of the total amount of 120 mmol present in the adult human body (209) Table 2 Classification of nutritional oxidants with protective roles against oxidative stress in thyroid diseases and their naturally occurring sources

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