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Additionally, cytosolic hydrogen peroxide (H 2 O 2 ) acts as the primary form of ROS responsible for stabilizing HIF-1

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Most rodent studies used: 10 micrograms/kg 100 micrograms/kg Administration routes varied by study: Intraperitoneal injection Subcutaneous injection Oral administration in drinking water Example reference: Sikiric et al., 2018 These dosages reflect controlled laboratory conditions and are not generalised outside experimental models

Gradually increase frequency and potentially concentration only after confirming tolerance