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Notably, Rhodiola rosea , Ginkgo biloba , and Withania somnifera (Ashwagandha) have garnered particular interest owing to their distinctive pharmacological characteristics that intersect with monoaminergic neurotransmission, neurotrophic support, modulation of the hypothalamic-pituitary-adrenal (HPA) axis, and anti-inflammatory signalingmechanisms that are consistently implicated in the pathophysiological framework of depression

From the TSA, the 95% CIs were adjusted using the alpha spending function approach to account for type I and II errors

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