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However, telomerase activity declines significantly with age in most human cells, contributing to the aging process and age-related cellular dysfunction

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By identifying the gut microbiome as an active player in the effects mediated by GLP-1 instead of a mere passive factor, this review puts forth a conceptual framework designed to clarify the variability in therapeutic responses and to inform the creation of personalized GLP-1 strategies that take the microbiome into account