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Because PDI bound by 4-HNE was identified in vivo, where GSH is present, it suggests that this compensatory mechanism may be limited by high levels of oxidative stress in which GSH concentrations are low [91]

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These may include: Irritation, redness, or slight swelling at the injection site Mild headaches Nausea Temporary discomfort Serious side effects are rare, but long-term safety data is still emerging

First , sermorelin is not FDA-approved for metabolic or weight management indications, and its use in these contexts remains off-label with limited evidence quality