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As potential inducer of HEP expression, phytoestrogens are promising dietary supplements to reduce iron overload and prevent any sequelae of iron-induced toxicities such as hyperferritinemia, coagulopathies and/or thromboembolism, which are prominent clinical manifestations in COVID-19 and PASC 94,144,494,495

Baaran et al

650 Methyl ferulic acid inhibits the expression of NOX4 protein and alleviates neuropathic pain in mice by regulating the expression of ACSL4 and GPX4, as well as ROS and iron content, suggesting that inhibiting NOX4-induced ferroptosis can reduce neuropathic pain

High quality human clinical trials testing the combination are limited