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In PD, this delicately regulated ecosystem is disturbed, resulting in microbial dysbiosis, which is defined by different compositional and functional alterations in the gut microbiota [23]

KO, n = 8 representative from 2 independent experiments, p = 0.9527) (a) , total tumor mass (WT, n = 6

In the brain of patients with mild cognitive impairment (MCI) and those with AD, the level of markers of oxidative damage to DNA, proteins, and lipids is increased, while the expression and activities of glutathione and antioxidant enzymes are reduced (reviewed in 102)

POR can generate ROS by extracting hydrogen from PUFAs or reducing Fe 3+ to Fe 2+ , reacting with adjacent lipids to form lipid hydroperoxides [38]