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They reported that histone proteins are lost in aging yeast cells, whereas histone protein overexpression and supplying extra histone proteins prolonged longevity 75

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The direct downstream targets of mTORC1 are ribosomal S6 kinase (p70S6K) and eukaryotic initiation factor 4Ebinding proteins (4EBP) which regulate protein translation, cell size and cell cycle progression 7,8