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This gut-mast cell axis explains why many people with seasonal allergies also have food sensitivities, and why gut health is fundamental to allergy management

This supports ongoing pharmacovigilance and patient safety

This intense inflammation is associated with damaging systemic events like oxidative stress, dysregulation of iron homeostasis, hypercoagulability and thrombus formation, acute respiratory distress syndrome, uncontrolled inflammation and organ failure (251257) (Figure 8)

In clinical trials, gastrointestinal adverse effects were the most common reason for treatment discontinuation, with approximately 9% of patients stopping Saxenda due to these symptoms