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However, this review also critically evaluates alternative explanations for the translational gap, including limited central nervous system penetration, insufficient pharmacodynamic target engagement, a mismatch between the drugs metabolic mechanisms and the amyloid-driven pathology of established AD, and the inherent limitations of preclinical models

It has also been linked with shifts in inflammatory markers in preclinical work

GLP-1 medications can suppress appetite so effectively that many users inadvertently reduce their protein and water intake both of which are critical for maintaining a strong and healthy moisture barrier

10.1016/0168-9452(85)90059-7 91 SuT.XuJ.LiY.LeiL.ZhaoL.YangH.et al