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Compared to placebo, treatment with watermelon extract containing 6 g/day of l-citrulline/l-arginine for 6 weeks exhibited reduced ankle and brachial systolic blood pressure (12 4 and 15 3 mmHg, respectively), ankle and brachial diastolic blood pressure (8 2 and 8 2 mmHg, respectively), as well as reducing the carotid augmentation index in obese pre- and hypertensive men [86]

Instead, we took advantage of three amino acid substitutions (E505Q, T527M, and K573P

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