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Tumor Necrosis Factor-Central Downstream Mediator of Chronic Inflammatory Response The cytokine tumor necrosis factor (TNF)- plays a central role in the pathogenic inflammatory process

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In summary, FOXO4-DRI exerts its anti-aging effects by inhibiting the binding of FOXO4 to P53, promoting P53 phosphorylation, and facilitating the translocation of p-P53 from the nucleus to the cytoplasm for its functional role

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