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Seco, A

Sjstrm L, Narbro K, Sjstrm CD, Karason K, Larsson B, Wedel H, et al

The injectable route of administration used in compounded tirzepatide levocarnitine may partially mitigate this concern

In IELs specifically, the activation of GLP-1R signaling suppresses phosphorylation of chainassociated protein kinase 70 (ZAP70) and its downstream target SH2 domaincontaining leukocyte protein 76 (SLP-76), leading to dampening of proximal T cell receptor signaling and reduced cytokine transcription