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Overall, compared with the large and growing amount of pre-clinical and mechanistic evidence highlighting the reward-modulating and thus potentially anti-addictive properties of GLP-1RAs, only a few studies have investigated thus far the potential use of these medications in clinical populations with alcohol- or other substance-use disorders

They influence body weight and body composition in different ways, while also making treatment easier to live with, as some strains can dial down nausea, diarrhea, or bloating

The hot plate was maintained at the temperature of 55C, and experimental protocol as previously described (1, 26)

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