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The reaction was measured at A 340 and A 540 simultaneously for 2 h

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8D and E) showed diffuse vacuolar degeneration and a large number of degenerating shrunken neurons

Next-generation sequencing identified Collinsella, Clostridium, and Streptococcus as the primary TMA-producing genera affectedall of which are suppressed or outcompeted by a healthy, Lactobacillus-rich microbiome