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Exposure to cigarette smoke contributes to bronchial inflammation and oxidative stress, which are significant factors in the pathophysiology of COPD

The review highlights FOXO4-DRI's unique mechanism as a peptide-based senolytic with high selectivity for senescent cells, while noting challenges for clinical translation including peptide delivery and stability

Adverse reactions following intramuscular (IM) injection have included anxiety, mild transient diarrhea, ataxia, nervousness, pruritus, transitory exanthema, and a feeling of swelling of the entire body

Therefore, it has been trialled and tested for this condition