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doi: 10.3389/fimmu.2025.1578940 Received 18 February 2025 Accepted 24 March 2025 Published 10 April 2025 Volume 16 - 2025 Edited by Fabrizio Fontana, University of Milan, Italy Reviewed by Bjrn Steen Sklhegg, University of Oslo, Norway Josephine Anthony, Meenakshi Academy of Higher Education and Research, India Updates Copyright 2025 Fang, Gao, Jiang, Li and Li

How This Works FOXO4-DRI is a synthetic peptide that selectively targets senescent cells by blocking the FOXO4p53 protein interaction [1] [2]

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Using validated chromameter technology (CIE L*a*b* colour space), independent expert clinical grading, and subject self-perception questionnaires, the data demonstrate clear, consistent improvement across all assessment methods and all facial measurement sites