how to taper off tirzepatide Weaning GLP-1 Medications: A Sustainable Approach How to Stop Taking Tirzepatide:

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It is established cardiac pharmacology, documented in the NEJM paper: "Glucagon and GLP-1 can exert positive chronotropic and inotropic effects on the heart." GLP-1 also contributes: GLP-1 receptor activation by itself produces a modest chronotropic effect this is why semaglutide and tirzepatide raise heart rate by 14 bpm

doi: 10.1080/19490976.2025.2467235 109 KistowskaMFeniniGJankovicDFeldmeyerLKerlKBosshardPet al