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Under conditions of oxidative stress, NRF2 associates with Keap1 and activates the expression of downstream target genes containing AREs, such as ferric heavy chain proteins (FTH1) and ferric light chain proteins (FTL), which encourages GSH synthesis and regenerates NADPH to compete with ROS production (83)

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DOI: 10.1053/j.gastro.2006.07.015

Network analysis revealed several metabolites exhibiting high connectivity, including S-adenosylhomocysteine, 5-methylthioadenosine, and diaminopimelic acid, reflecting their central roles within metabolic pathways rather than differential abundance between groups (Fig