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In Sinclairs protocols they are combined

NAC treatment, however, caused only moderate recovery of aspirin-induced apoptosis in HepG2 cells suggesting additional factor(s), other than altered GSH pool, which could play a role in inducing apoptosis by ASA

Dual ET(A)/ET(B) blockade with macitentan improves both vascular remodeling and angiogenesis in pulmonary arterial hypertension

For researchers investigating chronic low-grade inflammation (often called inflammaging), it offers a well-characterized tool compound for studying simultaneous antioxidant and anti-inflammatory responses without the systemic suppression that comes from corticosteroids or broad NSAIDs