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American Family Physician, 72(6), 1065-1070

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2.3 Cisplatin induces mitochondrial dysfunction When cisplatin enters the mitochondria, it acts directly on the inner mitochondrial membrane, leading to the impairment of the function of the electron transport chain, the reduction of ATP production and the induction of ROS generation ( Dysfunctional mitochondria release into the cytoplasm, it binds to with Apaf-1, triggering caspase-9, caspase-3 related cascade reactions that lead to apoptosis (Figure 2)

Cagrilintide (AM833) is a long-acting synthetic amylin and calcitonin receptor agonist studied in metabolic research