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3.2.2 Possible mechanisms H

In fact, analyses of hippocampal lipid composition in WT and APP/PS1 animals revealed a significant reduction of DHA contents in Low-DHA diet compared to the High-DHA diet, yet the amount of DHA in the Low-DHA condition was surprisingly higher than expected from the dietary supply (Table 3), which reflects an extremely efficient ability to preserve brain DHA even when subjected to negligible levels in the diet (Daz et al., accepted)

Some studies have also shown that ferroptosis inducers can activate ERK-eIF2 mediated by endoplasmic reticulum stress ATF-ATF4-CHOP cascade without inducing apoptosis

Some studies point to the ability of serine, a nonessential amino acid, to boost glutathione production, potentially through increased cysteine availability and a decrease of hypermethylation