Cell Metab 31(3):472492 Gounder M, Johnson M, Heist RS, Shapiro GI, Postel-Vinay S, Wilson FH, Garralda E, Wulf G, Almon C, Nabhan S, Aguado-Fraile E, He P, Romagnoli M, Hossain M, Narayanaswamy R, Sadou-Dubourgnoux A, Cooper M, Askoxylakis V, Burris HA, Tabernero J (2025) Mat2a inhibitor ag-270/s095033 in patients with advanced malignancies: a phase i trial
Current evidence supports glutathione's potential as a depigmenting agent but underscores the need for rigorous, large-scale clinical trials to establish long-term safety, optimal dosing, and standardized applications, and until such data are available, clinicians and consumers should exercise caution to ensure safe and effective dermatological practices, particularly with intravenous use
Rat studies have shown that the peptide can both stimulate collagen production in normal skin and help degrade extra-large collagen aggregates in scar tissue, suggesting context-dependent effects that promote normalized tissue structure (Pickart & Margolina, 2018)
Lower concentrations mean larger volumes (slightly less convenient) but are more forgiving of small measurement variations
