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Chiral nanostructures have been produced using nanofabrication techniques such as lithography 7 and molecular self-assembly 8,9,10,11 , but large-scale and simple fabrication methods for three-dimensional chiral structures remain a challenge

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The position this article takes, given those three valid critiques, is that the mechanism evidence is strong enough, the delivery evidence is biologically plausible enough, and the safety window is wide enough that the recommendation is defensible

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