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The goals of future clinical trials should be to establish the therapeutic range of melatonin dosage and the appropriate timing of administration to improve clinical condition and outcome

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Thalidomide is associated with edema, sinus bradycardia, venous thromboembolism, and lenalidomide is associated with hypersensitivity myocarditis, and high-dose interleukin-2 is associated with fulminant myocarditis