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Patients with these risk factors should discuss screening and supplementation strategies with their GP, particularly if experiencing symptoms such as fatigue, paraesthesia, glossitis, or cognitive changes suggestive of deficiency

Functions as a for metabolic reaction required for synthesis of purines and pyrimidines: co-enzyme The reaction depends on methyl cobalamin as a co-factor and is also dependent on folate, in which the methyl group of methyltetrahydrofolate is transferred to homocysteine to form methionine and tetrahydrofolate

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Some people need higher doses if they have absorption issues or severe deficiencies