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When the gut lining is compromised, more toxins and undigested food particles enter the bloodstream and head straight to the liver

High glucose levels increase tricarboxylic acid cycle intermediates, delivering excess electrons to the electron transport chain (ETC.)

In iron-deficient states, GPX4 activity declines, leading to reactive oxygen species (ROS) accumulation and lipid peroxidationpotent triggers of eryptosis (Rochette et al., 2022)