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Genetic Testing and Personalized Tirzepatide Response The PlexusDx Precision Peptide Genetic Test analyzes GLP1R (rs6923761), GIPR (rs1800437), FTO (rs9939609), and MC4R (rs17782313) variants that relate to GLP-1 and related signaling pathways

Yet, some patients may not want to stay on injectable versions of GLP-1 weight loss drugs, such as semaglutide and tirzepatide, long term

Contraindications Tirzepatide, whether compounded or brand-name, should not be used by individuals with a personal or family history of medullary thyroid carcinoma, Multiple Endocrine Neoplasia syndrome type 2, severe gastroparesis or gastrointestinal disease, or during pregnancy

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