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In childhood, deficiencies in vitamins B6, B9, and B12 can lead to neurological conditions such as polyneuropathy, seizures, epilepsy, and encephalopathy (, , , , , )

doi: 10.1038/s41598-018-28477-9 407 NaviauxRKNaviauxJCLiKBrightATAlaynickWAWangLet al

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2.1.1 Impact of energy and protein deficiency on tissue repair Esophagectomy involves extensive tissue resection, digestive tract reconstruction, and anastomotic healing, a process that demands a substantial supply of energy and protein as material substrates ( 2.1.2 Impact of micronutrient and vitamin deficiency on immune function In addition to macronutrients, various micronutrients and vitamins play critical coenzyme or catalyst roles in maintaining immune homeostasis and promoting tissue repair ( 2.2 Pathophysiological mechanisms of the systemic inflammatory response 2.2.1 Tumor-Induced systemic inflammatory microenvironment The association between chronic inflammation and the development and progression of cancer is a fundamental tenet of oncology ( 2.2.2 The inflammatory cascade activated by surgical trauma The major surgical trauma of esophagectomy inevitably leads to extensive tissue damage, ischemia-reperfusion injury, and endotoxin translocation, thereby triggering a violent acute inflammatory response ( 2.2.3 The role of the cytokine network in complications Cytokines play a double-edged sword role in the development of postoperative complications