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GPX has long been known to be a player in H 2 O 2 metabolism in mammalian cells, but only began to be seriously studied in plants following the description of sequences homologous to the animal enzymes in the 1990s

doi: 10.1042/EBC20200018 63

Melatonin is unique among endogenous antioxidants because of its efficiency and ubiquity: it can donate electrons to neutralize radicals, and its metabolites (like AFMK) are also free radical scavengers, yielding a cascade of antioxidant actions

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