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These may include: Systemic corticosteroids such as prednisone (2060 mg/day) Anti-inflammatory medications such as salicylates (aspirin) Dapsone 50100 mg/d Ciclosporin High doses of oral antibiotics such as erythromycin (2 g/day) for secondary infection Isotretinoin commenced in low dose after control has been obtained with systemic steroids Tumour necrosis factor-alpha (TNF-) inhibitors, such as infliximab

The outcomes of other variables meta-regression were non-significant (Table 4)

For example, mapping the interactomes of HSP70 and HSP90 has clarified that these proteins not only ensure correct folding but also influence autophagic decision-making and UPS performance, 548,549 highlighting their integrative role in proteostasis governance

PloS ONE 6 , e19194 (2011)