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After the model was expanded to include GS-H 2 Q adduct formation as a function of its reduction potential, it was then combined with the Reed glutathione model 21 in order to simulate how the quinone redox-metabolism of doxorubicin influenced the glutathione metabolism

O.et al (2019)

These complications affect central hemodynamics, for example, an increase in pressure in the abdominal cavity to 20 centimeters of water column can lead to compression of the inferior vena cava, which reduces venous return