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As the impairment of cutaneous sympathetic nerves is more remarkable in the extremities than that in the thorax with PD progression 45 , the lack of -synuclein fibrils in the legs is likely to represent the loss of -synuclein fibril-bearing sympathetic nerves

The 1 H loop was tuned to 400.3 MHz for localizing the mouse brain and shimming, while the 2 H loop was tuned to 61.4 MHz for acquiring 2 H spectra

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