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Meanwhile, TGF- downregulates Smad7 expression, relieves the negative regulation of Smad2/3, and amplifies the fibrosis signal (Huang et al., 2023

Mechanistically, this approach leverages chemotherapy to induce immunogenic cell death, whereby the release of danger signals and tumor antigens boost the anti-cancer efficacy of immunotherapy (234)

At the family level (Figure S6A), the network showed high complexity, with Sutterellaceae serving as a central node highly connected to Prevotellaceae and Lachnospiraceae

It's a medically supervised intervention that requires ongoing lab monitoring, dose adjustments based on response, and integration with lifestyle factors that determine whether the peptides translate into meaningful long-term outcomes