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It should be emphasized, however, that the STEP-HFpEF trial was not designed or powered to assess clinical events, and the impact of semaglutide on hard endpoints in heart failure remains to be determined

8 Compared with placebo, once weekly tirzepatide significantly reduced the combined risk of cardiovascular death or worsening HF events (hospitalisation or an urgent hospital visit requiring intravenous therapy)

When protein and strength activity are inadequate, the patient may lose more lean mass than desired

16 Because the therapeutic potential of natural GLP-1 is limited due to its rapid degradation by the enzyme dipeptidyl peptidase 4 (DPP-4), GLP-1 analogs have been developed that are DPP-4 resistant