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Description

The role of inflammatory factors and anti-inflammatory factors produced by M1/M2 macrophages in synovial membrane in OA has also been established by some studies, suggesting that macrophage polarization plays a regulatory role in OA (67, 68)

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This creates not only a crosstalk between integrins but a crosstalk between integrins and their various membrane partners such as cadherins ( At least two integrins found in the TM/SC are known to have a tunable conformation and thus their activity is likely to be altered depending upon the composition and 3D architecture of the ECM in the TM/SC

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Carr KA, Epstein LH

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