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Furthermore, during heart failure, cfDNA mediates intercellular communication by interacting with nucleic acid sensors (e.g., TLR9, cGAS) on cell membranes or intracellular compartments, potentially triggering necroptosis and pyroptosis [266]

This paradigm shift underscores that therapeutic strategies must target the underlying metabolic dysfunction, not just symptomatic pain relief

oleifera leaves are considered safe based on toxicological studies in rats, which showed good tolerability without any mutagenic or genotoxic effects (392)

Other potentially attractive therapeutic strategies that could target the disrupted redox balance underlying halted reticulocyte maturation are amino-acid supplementation with L-glutamine, vitamin E supplementation, and NAC