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Despite their notable absence in CM, alterations in the SF3B1 gene are not unique to MM - similar mutations have also been detected in uveal melanoma, breast cancer, myelodysplastic syndromes, and chronic lymphocytic leukemia, including mutation hotspots such as codon 700, 622, 625, 662, and 666 (99, 113)

When hydroxocobalamin is given in high doses (such as during cyanide poisoning treatment), unique effects can be observed: patients often experience a transient reddening of the skin or mucous membranes and a reddish discoloration of the urine due to drug excretion

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Many patients struggle with emotional eating, denial, or low motivation