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A 2025 randomised, placebo-controlled clinical trial (n=180 adults with ischaemic cardiomyopathy, LVEF 45%, NYHA grade IIIII) published in the American Journal of Cardiovascular Drugs examined NAD+ supplementation in this population providing rare human clinical data on direct NAD+ administration in a cardiovascular disease context and adding to the growing translational evidence base for NAD+ in heart failure research