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All in all, astrocytic responses in AD are complex and disease stage-specific: in the early, compensated phase of AD (manifested by mild cognitive impairment) astrocytes, together with other neuroglia become reactive and arguably protect brain tissue

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It says indigestion severity often correlates with how fast the dose is escalated, and that faster schedules increase both indigestion risk and discontinuation rates while gradual escalation improves tolerability without sacrificing efficacy

Design, synthesis and biological evaluation of novel catalpol derivatives as potential pancreatic cancer inhibitors