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A 2025 review published in PMC ( Alopecia and Semaglutide: Connecting the Dots for Patient Safety , Branyiczky et al., International Journal of Dermatology ) specifically highlights micronutrient depletion particularly iron, zinc, vitamin D, and biotin as a primary pathway, noting these are well-recognised triggers for telogen effluvium. Hormonal disruption

Both the leptin protein and the leptin receptor (LepR) have been detected in discs and are positively correlated with age and degeneration severity ( 2.2 Adiponectin Adiponectin, a glycoprotein that is uniquely expressed by adipocytes, could maintain energy balance and suppress inflammation or apoptosis in various tissues by binding to adiponectin receptors (AdipoR1/2)

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