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In Phase 2 trials, participants on the highest dose (12mg weekly) lost an average of 24.2% of their body weight over 48 weeks, results that surpass both semaglutide and tirzepatide at their respective trial endpoints

In SURMOUNT 4, all participants received the maximum tolerated dose of tirzepatide for 36 weeks and were then randomized 1:1 to continue tirzepatide or receive placebo until 88 weeks

We also discuss recent and ongoing clinical studies investigating the effects of choline supplementation and the potential use of choline-derived metabolites as biomarkers for therapy response

Increased Fluid Intake : Some patients may drink more water due to appetite suppression or lifestyle changes, leading to increased urination