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Contraindications : Individuals allergic to cobalt or any other ingredient in the injection should avoid B12 injections

The neurologic complications of pernicious anemia, however, can persist even after B12 stores are fully replaced

Health status considerations: Generally healthy adults with physician clearance, individuals without contraindications (pregnancy, active malignancy, severe organ disease), those willing to commit to proper administration protocols and monitoring, and patients who understand the research-purposes-only status and informed consent requirements