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Potential for Hypoglycemia: While not common, there is a risk of hypoglycemia (low blood sugar), especially when Tirzepatide is used in combination with other glucose-lowering medications like insulin or sulfonylureas

Crohns causes swelling and thickening when it affects bowel tissues, which may block the bowel passage

Discontinuation rates due to adverse events for patients randomized to placebo or orforglipron were 4.8% (orforglipron from Wegovy), 7.6% (placebo from Wegovy), 7.2% (orforglipron from Zepbound) and 6.3% (placebo from Zepbound)