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PDE5 inhibitors - sildenafil (Viagra), tadalafil (Cialis), vardenafil (Levitra) (Moderate to major interaction - use caution): L-Arginine and L-Citrulline can have additive effects on vasodilation when combined with PDE5 inhibitors

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Microbiome 11 , 212 (2023)

Summary: GLP-1 medications do not directly affect periods, but the significant weight loss they cause can indirectly influence menstrual regularity through hormonal and metabolic changes