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The independent effects included in the model were treatment, region, strata (renal function for PIONEER 5 and insulin regimen for PIONEER 8), background medication and interaction between treatment and background medication as categorical fixed effects and baseline value as a covariate, all nested within visit, and using an unstructured residual covariance matrix

the peptide-copper complex stimulates collagen production, accelerates wound healing and tissue contraction, and exerts anti-inflammatory effects across skin and other tissues