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Differences in APAP PK, pharmacodynamics (PD), toxicity profile and efficacy between individuals and populations have been widely noted (Zuppa et al., 2011

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53,58,59,60,61 However, other studies have suggested that BECs, as facultative stem cells, directly transdifferentiate into hepatocytes in injured livers

Its regulation is also different from that of NRF2, which is mainly regulated by N-glycosylase 1 (NGLY1) and DNA loss inducer 1 homolog 2 (DDI2) [13, 14]