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This medication works in several ways to reduce hunger: It slows down how quickly food leaves your stomach, helping you feel full longer It acts directly on appetite centers in your brain to reduce hunger signals It can decrease your interest in high-fat, calorie-dense foods Research shows that people on semaglutide typically consume about 24% fewer calories than those on placebo, which explains the significant weight loss many experience

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doi: 10.1016/S0891-5849(00)00309-9